Research Interest: Causal inference, Biostatistics, Epidemiology, Statistical learning, Survey data analysis, Bayesian methodologies.
Keywords: Observational data analysis, Time-dependent confounding, High-dimensional propensity score, Mediation analysis, Marginal structural models, Survival analysis, Machine Learning, Longitudinal data analysis.
Editorial / Commentary
Invited Editorial
- Karim, M. E. (2013) Can joint replacement reduce cardiovascular risk? BMJ. 347:f6651
Letter to the Editor / Reply
- Karim, M. E.; Petkau, J.; Gustafson, P.; Platt, R.W. (2018) Authors' reply: Letter to the Editor: Regarding Karim et al. (SMMR, Vol 27, Issue 6, 2018). Statistical Methods in Medical Research. First Published November 5, 2018.
- Karim, M. E.; Gustafson, P.; Petkau, J.; Tremlett, H. (2016) The Authors reply. American Journal of Epidemiology. 184 (11): 857-858.
- Shirani, A.; Zhao, Y.; Karim, M. E.; Evans, C.; Kingwell, E.; van der Kop, M.; Oger , J.; Gustafson, P.; Petkau, J.; Tremlett, H. (2013) Interferon Beta and Long-term Disability in Multiple Sclerosis. JAMA Neurology. 70(5):651-653.
Response
- Shirani, A.; Zhao, Y.; Karim, M. E.; Kingwell, E.; Gustafson, P.; Petkau, J.; Tremlett, H. (2016) Observational studies of disease modifying therapies for multiple sclerosis: methodological challenges and opportunities. BMJ. Published online: 22 November 2016.
- Platt RW, Karim ME, Debray TPA, Copetti M, Tsivgoulis G, Waubant E, Hartung HP (2019) Comparison of fingolimod, dimethyl fumarate and teriflunomide for multiple sclerosis: when methodology does not hold the promise. Journal of Neurology, Neurosurgery, and Psychiatry. Published on: 6 March 2019.
First-authored
- Karim, M. E.; Khan, J.R. (2018) Guidance for Practitioners on the Choices of Software Implementation for Frailty Models: Simulations and An Application in Determining the Birth Interval Dynamics. Journal of Statistical Research, 52(1) 1-17.
- Karim, M. E.; Pang, M.; Platt, R.W. (2018) Can We Train Machine Learning Methods to outperform the High-dimensional Propensity Score Algorithm? Epidemiology, 29(2): 191-198.
- Related: Presented at an invited session at 2016 IBC conference.
- Karim, M. E.; Petkau, J.; Gustafson, P.; Platt, R.W.; Tremlett, H. and BeAMS study group. (2018) Comparison of Statistical Approaches Dealing with Time-dependent Confounding in Drug Effectiveness Studies. Statistical Methods in Medical Research. 27(6) 1709-1722.
- Related: supporting information
- Karim, M. E.; Platt, R.W. and BeAMS study group. (2017) Estimating inverse probability weights using super learner when weight-model specification is unknown in a marginal structural Cox model context, Statistics in Medicine, 36(13):2032-2047.
- Related: Travel Award from the Statistical Society of Canada Biostatistics Section, 2016 (details)
- Karim, M. E.; Petkau, J.; Gustafson, P.; Tremlett, H. and BeAMS study group. (2016) On the application of statistical learning approaches to construct inverse probability weights in marginal structural Cox models: hedging against weight-model misspecification. Communications in Statistics - Simulation and Computation, 46 (10): 7668-7697.
- Karim, M. E.; Gustafson, P.; Petkau, J.; Tremlett, H. and BeAMS study group. (2016) Comparison of Statistical Approaches for Dealing With Immortal Time Bias in Drug Effectiveness Studies. American Journal of Epidemiology, 184 (4): 325-335.
- Related: supporting information
- Related: Student Research Presentations Award in the 2015 annual SSC Meeting (details, photo)
- Related: Travel Award from the endMS Research and Training Network
- Related: Follow-up: Letter to editor, Reply
- Karim, M. E.; Gustafson, P. (2016) Hypothesis Testing for an Exposure-Disease Association in Case-Control Studies under Non-differential Exposure Misclassification in the presence of Validation Data: Bayesian and Frequentist Adjustments. Statistics in Biosciences. 8 (2): 234–252.
- Related: Presented at an invited session at a conference.
- Karim, M. E.; Gustafson, P.; Petkau, J.; Zhao, Y.; Shirani, A.; Kingwell, E.; Evans, C.; van der Kop, M.; Oger , J.; Tremlett, H. (2014) Marginal structural Cox models for estimating the association between beta-interferon exposure and disease progression in a multiple sclerosis cohort. American Journal of Epidemiology; 180 (2): 160-171.
- Related: supporting information
- Related: Selected as one of the American Journal of Epidemiology (AJE)’s 2014 top 10 Articles of the Year (announcement, open collection, news, certificate)
- Related: Travel Award from the endMS Research and Training Network
From Research Collaborations
- Wong, H; Ouyang, Y; Karim, M.E. (2019) “The randomization-induced risk of a trial failing to attain its target power: Assessment and mitigation”, Trials, DOI: 10.1186/s13063-019-3471-8
- Atiquzzaman M., Karim M.E., Kopec J, Wong, Wong H, Anis A. (2018) Role of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in the Association between Osteoarthritis and Cardiovascular Diseases: A Longitudinal Study. Arthritis & Rheumatology (Accepted, citations will be updated soon).
- Basham C, Karim ME (2019) Multimorbidity prevalence in Canada: A Comparison of Northern Territories with Provinces, 2013/14. International Journal of Circumpolar Health. 78:1, 1607703, DOI: 10.1080/22423982.2019.1607703.
- Liu P, Quinn R, Karim ME, Bello A, Tam-Tham H, Weaver R, Ronksley P, Quan H, Strippoli G, Manns B, Hemmelgarn B, Tonelli M, Ravani P. (2019). Nephrology consultation and mortality in people with chronic kidney disease: a population-based study. Canadian Medical Association Journal. 191 (10) E274-E282; DOI: 10.1503/cmaj.181372.
- Gustafson, P.; Karim, M. E. (2018) When Exposure is subject to Nondifferential Misclassification, are Validation Data helpful in Testing for an Exposure-Disease Association? The Canadian Journal of Statistics. DOI: 10.1002/cjs.11490, First published: 03 March 2019.
- Kwon, JY., Karim, M. E., Topaz, M., Currie, L. (2018). Nurses "seeing forest for the trees" in the age of machine learning. Computers, Informatics, Nursing. DOI: 10.1097/CIN.0000000000000508 , PMID: 30688670 Issn Print: 1538-2931 Publication Date: 2019/01/01.
- Ahmed K, McVeigh T, Cerneviciute R, Mohamed S, Tubassam M, Karim ME, Walsh SR. (2018). Effectiveness of Contrast-Associated Acute Kidney Injury Prevention Methods; A Systematic Review and Network Meta-Analysis. BMC Nephrology; 19(1):323. doi: 10.1186/s12882-018-1113-0.
- Bacak, V; Karim, M. E. (2018) The Effect of Serious Offending on Health: A Marginal Structural Model. Society and Mental Health (First Published October 3, 2018).
- Fontela, P.S.; Quach, C; Karim, M. E.; Willson, D.; Gilfoyle, E.; McNally, J.D.; Gonzales, M.; Papenburg, J.; Reynolds, S.; Lacroix, J.; on behalf of Canadian Critical Care Trials Group and Pediatric Acute Lung Injury and Sepsis Investigators. (2017) Determinants of Antibiotic Tailoring In Pediatric Intensive Care: a National Survey, Pediatric Critical Care Medicine: Published online: June 28, 2017 DOI: 10.1097/PCC.0000000000001238.
- Zhang, T.; Shirani, A.; Zhao, Y.; Karim, M. E.; Gustafson, P.; Petkau, J.; Evans, C.; Kingwell, E.; van der Kop, M.; Zhu, F.; Oger , J.; Tremlett, H. (2015) Beta-interferon exposure and onset of secondary progressive multiple sclerosis, European Journal of Neurology. 22(6):990–1000.
- Shirani A., Zhao, Y. Petkau J., Gustafson P., Karim, M. E., Evans C., Kingwell E., van der Kop M.L., Oger j. and Tremlett H. (2015) Multiple sclerosis in older adults: the clinical profile and impact of interferon beta treatment, BioMed Research International. DOI: 10.1155/2015/451912, 2015 (2015), ID 451912:1-11.
- Gibbs, E.; Karim, M. E.; Oger , J; the Steering Committee of the BENEFIT study (Gilles Edan, Mark S. Freedman, Hans Peter Hartung, Ludwig Kappos, David Miller, Xavier Montalbán, Dirk Pleimes, Christoph Pohl, Chris Polman, Rupert Sandbrink). Antibody dissociation rates are predictive of neutralizing antibody (NAb) course: A comparison of interferon beta-1b-treated patients with transient versus sustained NAbs. Clinical Immunology. 157(1):91–101.
- Shirani, A.; Zhao, Y.; Karim, M. E.; Petkau, J.; Gustafson, P.; Evans, C.; Kingwell, E.; van der Kop, M.; Oger , J.; Tremlett, H. (2014) Investigation of heterogeneity in the association between interferon beta and disability progression in multiple sclerosis: an observational study. European Journal of Neurology. 21(6):835-44.
- Shirani, A.; Zhao, Y.; Karim, M. E.; Evans, C.; Kingwell, E.; van der Kop, M.; Oger , J.; Gustafson, P.; Petkau, J.; Tremlett, H. (2012). Association between use of interferon beta and progression of disability in patients with relapsing-remitting multiple sclerosis. Journal of the American Medical Association (JAMA). 308(3):247-256.
- Related: Journal Media Release (JAMA media link, 46 papers selected each year)
- Related: Video Interview and Additional Video Comments.
- Related: Selected for an Accompanying Editorial (Editorial Link).
- Related: Extensive Media Attention: 4 T.V. interviews (live on CTV National, taped on multiple evening news networks), and extensive news coverage, including NY Times, Fox News, Time, CBC News, Metro News, Global BC, Vancouver Sun, MS Society of Canada, UBC media, UBC Stat Dept News.
- Related: Follow-up: Letter to editor, Reply, Commentary, Citations.
- Related: Officially recognized in the ‘2013 International Year of Statistics – Recognizing the Contributions of Statistics to Society worldwide’ poster.
- Rahman, P.K.; Matsui, N.; Ikemoto, Y.; Karim, M. E. (2007). Intergenerational Mobility in Poverty State of Chronically Poor in Rural Bangladesh: A Markov Chain Model Approach. Asian Economic Review, Yamaguchi University, Vol-66, No.1, 2007 (mirror)
- Anema A., Karim M.E., Milloy M.J., Wood E., McCandless L. Directed Acyclic Graphs to Identify Confounders: A Case Study Exploring the Impact of Hunger on Virological Suppression Among HIV+ Illicit Drug Users Receiving HIV Treatment. In: Health of HIV Infected People: Food, Nutrition and Lifestyle with Antiretroviral Drugs [Volume 1]. Watson RS (Ed.) 2015. Elsevier Publishing Inc. [preview]
Videobook
- Karim (2013) R Graph Essentials, Packt Publishing, ISBN: 1782165460, ISBN 13: 9781782165460
- Available for order via Packt Publishing or O’Reilly
- Included as Chapter 3 of Learning Path: Data Visualization with R, released Sept 2016, Packt Publishing, ISBN: 9781787122239
- Yanling; Cai, Jing; Chen, Jessica; Golchi, Shirin; Guan, Meijiao; Karim, M. E.; Liu, Yang; Tomal, Jabed; Xiong, Chao; Zhai, Yongliang; Lum, Conroy; Welch, W.J.; Zidek, James V. (2016) An empirical experiment to assess the relationship between the tensile and bending strengths of lumber, Technical report 276, Department of Statistics, University of British Columbia.
- Shirani, A and Zhao, Y and Karim, M. E and Evans, C and Kingwell, E and van der Kop, M and Oger , J and Gustafson, P and Petkau, J and Tremlett, H (2013). An observational study from British Columbia, Canada: interferon-beta treatment and disability progression in relapsing-remitting multiple sclerosis. siicsalud (Neurology) [Authors' Report]
- See the list of unpublished reports / drafts here.
Thesis
- Causal Inference Approaches for Dealing with Time-dependent Confounding in Longitudinal Studies, with Applications to Multiple Sclerosis Research
- under supervision of Paul Gustafson, Petkau, John, with Tremlett, Helen UBC in the supervisory committee (PhD)
- supported by a PhD studentship from the Multiple Sclerosis Society of Canada and by grants from the National MS Society and the Canadian Institutes of Health Research.
- Evaluating the Performance of Hypothesis Testing in Case-Control Studies with Exposure Misclassification, using Frequentist and Bayesian Techniques
- under supervision of Paul Gustafson, UBC (masters)
- Comparative Study on the different approaches of Frailty Model: A simulation Study
- under supervision of A.H.M. M. Latif, ISRT, DU (masters, abstract)
- Modeling the Daily Rainfall Occurrence: A stochastic approach
- under supervision of S.S. Hossain, ISRT, DU (undergraduate, abstract)
