Research‎ > ‎

Research Talks

 

·        Invited Conference Presentations:

1.      Karim ME “Healthcare data analytics in the era of machine learning and artificial intelligence”, LifeSciences BC Access to Innovation, Vancouver Convention Centre West, Vancouver, Feb 5th, 2020. URL: https://lifesciencesbc.ca/wp-content/uploads/2019/08/Access-to-Innovation-020320009-1.pdf [Last accessed: 4 February, 2020]

2.      Karim ME; Tremlett H; Zhu F; Petkau, J; Kingwell, E “Dealing with treatment-confounder feedback and sparse follow-up in longitudinal studies - an application of the marginal structural model in a multiple sclerosis cohort”;

§  Invited session on ‘Novel methods and applications in the estimation of longitudinal effects’, Statistical Society of Canada Annual Meeting 2020, May 31-June 3, 2020, Carleton University, Ottawa, Ontario (scheduled).

§  Invited Session - 7: Biostatistics and data science; 2nd International Conference on Applied Statistics 2019, Dhaka University, Bangladesh; December 27-29, 2019.

3.      Karim, M.E. “High-dimensional propensity score adjustment for analyzing electronic healthcare data: recent advances”, Statistical issues in administrative data, Banff International Research Station, Banff, Feb 2019.

4.      Karim ME; Pang, M.; Platt, R. "Comparing approaches for Confounding Adjustment in Secondary Database Analyses: High-Dimensional Propensity Score versus two machine learning algorithms: Random Forest and Elastic Net", invited session on 'Statistical Methods to Improve Drug and Vaccine Safety Surveillance Using Big Healthcare Data', XXVIIIth International Biometric Conference, Victoria Convention Centre, Victoria, Canada 10 - 15 July, 2016.

5.      Karim ME; Gustafson, P.; Petkau, J.;  Shirani, A.;  Zhao, Y.;  Kingwell, E.;  van der Kop, M.;  Oger, J.; UBC MS Clinic Neurologists.; Tremlett, Helen "Causal inference tools for estimating the effect of beta-interferon exposure in delaying disease progression in a relapsing-remitting multiple sclerosis cohort data obtained from observational sources" 2013 endMS Conference in December 2013, St. Sauveur, Quebec. [Invited poster presentation]

6.      Karim ME; Gustafson, P "Adjusting for Exposure Misclassification in Bayesian Hypothesis Testing in Case-Control Studies", The First International Conference on Theory and Applications of Statistics; Dhaka University, Bangladesh; December 26-28, 2010.

 

·        Invited Research Seminar Presentations:

1.      Karim, M. E. "Use of machine learning methods in the context of causal inference”, BC-CfE Forefront lecture series, May 13th in Hurlburt Auditorium, St. Paul’s hospital, Vancouver. (Scheduled)

2.      Karim, M. E. "Best practices of various propensity score methods in comparative effectiveness research", Biogen ALIGN meeting, Montreal, June 12, 2019.

3.      Karim ME; Pang, M.; Platt, R. "Can We Train Machine Learning Methods to Outperform the High-dimensional Propensity Score Algorithm?"

§  Department of Community Health Sciences & George and Fay Yee Centre for Healthcare Innovation, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, May 9, 2019.

§  Biogen Symposium on Statistical Methods in Multiple Sclerosis, Cambridge, Massachusetts. November 2018.

§  Departmental Seminar Series, Department of Statistics & Actuarial Science, Simon Fraser University, April 6, 2018

§  Research seminar, Institute of Statistical Research and Training, University of Dhaka, Bangladesh, June 6th, 2018

4.      Karim, M. E. "Statistical Learning Approaches and Health Administrative Data", Big Data and Depression Care, St. Paul’s Hospital, Vancouver, 27 March 2018.

5.      Karim, M. E. "Comparing approaches for Confounding Adjustment in Secondary Database Analyses: High-Dimensional Propensity Score versus two machine learning algorithms", Drug Safety and Effectiveness Cross-Disciplinary Training  / Drug Safety and Effectiveness Network (DSECT/DSEN) Monthly Seminar Series, Online Seminar, Mar 23, 2017. Link: http://www.safeandeffectiverx.com/events/view/52 (100 registered nationwide, which is the maximum limit accommodated by the seminar organizers.)

6.      Karim, M.E. “Application of Machine Learning Techniques to Improve Causal Inference in Observational Studies.”, Seminar at School of population and public health, UBC, April 21, 2017.

7.      Karim, M. E. “Automated Confounding Control in Comparative Effectiveness Research: Help or Hype?” Work in Progress Seminar, Hurlburt Auditorium, St. Paul's Hospital, Vancouver, April 12, 2017.

8.      Karim ME (2017) "Marginal Structural Models in Multiple Sclerosis: Recent Developments and Suitable Alternatives", Biogen Symposium on Statistical Methods in Multiple Sclerosis, Cambridge, Massachusetts. November 2017.

9.      Karim ME; Gustafson, P.; Petkau, J.; Tremlett, H.; The BeAMS study group "Comparison of Statistical Approaches Dealing with Immortal Time Bias in Drug Effectiveness Studies":

§  January 19, 2016, Biostatistics seminar, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC.

§  February 8, 2016, Causal inference journal club, Faculté de pharmacie, Université de Montréal, Montreal, QC.

§  March 8, 2016, Epidemiology seminar, Centre for Clinical Epidemiology Jewish General Hospital, Lady Davis Research Institute, Montreal, QC.

§  June 30, 2016, Department seminar, Landmark Center, Harvard Medical School & Harvard Pilgrim Health Care Institute, Boston, MA.

10.   Karim ME. “Application of Propensity Scores in Epidemiology”, December 2010, Institute of Statistical Research and Training Seminar, University of Dhaka, Bangladesh.

11.   Rahman, P.K. and Matsui, N. and Ikemoto, Y. and Karim ME (2007). “Livelihoods of Chronically Poor in Rural Bangladesh”. International Workshop on “Chronic  Poor in Bangladesh”. 17-19 March 2007, The Institute of Oriental Culture, University of Tokyo, Japan.

 

·        Contributed Conference Presentations

1.      Karim ME; Tremlett H; Zhu F; Petkau, J; Kingwell, E “Dealing with treatment-confounder feedback and sparse follow-up in longitudinal studies - an application of the marginal structural model in a multiple sclerosis cohort”; Topic-contributed paper session, Novel perspectives on the estimation of longitudinal effects; Joint Statistical meetings, Philadelphia, Pennsylvania; August 1-6, 2020 (scheduled).

2.      Karim, M. E.*; Pang, M.; Platt, R. "Can We Train Machine Learning Methods to Outperform the High-dimensional Propensity Score Algorithm?"

§  Section on Statistics in Epidemiology, Joint Statistical Meetings, August 1, 2018.

§  International Society for Clinical Biostatistics (ISCB) Annual Conference, August 2018 Melbourne, Australia

§  Annual Meeting of the Statistical Society of Canada, Calgary, May, 2019

3.      Karim, M. E. *; Pang, M.; Platt, R. "Comparing approaches for Confounding Adjustment in Secondary Database Analyses: High-Dimensional Propensity Score versus two machine learning algorithms: Random Forest and Elastic Net", International Society for Clinical Biostatistics (ISCB) Annual Conference, 21-25 Aug 2016 Birmingham, UK.

4.      Karim, M. E. *; Platt, R., Tremlett, H.; The BeAMS study group "Estimating Inverse Probability Weights using Super Learner when Weight-Model Specification is Unknown in a Marginal Structural Cox Model Context: An Application to Multiple Sclerosis",

§  session on "Biostatistics Applications", Annual Meeting of the Statistical Society of Canada, Brock University, St. Catharines, May 29 - June 1, 2016.

§  XXVIIIth International Biometric Conference, Victoria Convention Centre, Victoria, Canada 10 - 15 July, 2016.

§  International Society for Clinical Biostatistics (ISCB), Annual Conference, 9-13 July 2017 Vigo, Spain.

5.      Karim, M. E. *; Gustafson, P.; Petkau, J.; Tremlett, H.; The BeAMS study group "Comparison of Statistical Approaches Dealing with Immortal Time Bias in Drug Effectiveness Studies", session on "Biostatistics in Action 1", Annual Meeting of the Statistical Society of Canada, Dalhousie University, Halifax, Nova Scotia, June 14-17, 2015.

6.      Karim, M. E. *; Petkau, J.; Gustafson, P.; Tremlett, H.; The BeAMS study group; "The Performance of Statistical Learning Approaches to Construct Inverse Probability Weights in Marginal Structural Cox Models: A Simulation-based Comparison", The 3rd annual Statistical Society of Canada Student Conference, Dalhousie University, Halifax, Nova Scotia, June 13, 2015.

7.      Karim, M. E. *; Gustafson, P.; Petkau, J.;  Shirani, A.;  Zhao, Y.;  Kingwell, E.;  van der Kop, M.; Oger, J.; Tremlett, H. "Estimating the effect of beta-interferon exposure in delaying disease progression in relapsing-remitting multiple sclerosis patients using causal inference tools", Session on 'Novel Methods for Analysis of Survival and Longitudinal Data', Section on Statistics in Epidemiology, 2014 Joint Statistical Meetings, August 2-7, 2014.

8.      Karim, M. E. *; Gustafson, P.; Petkau, J.;  Shirani, A.;  Zhao, Y.;  Kingwell, E.;  van der Kop, M.; Oger, J.; Tremlett, H. "Logrank tests with the inverse probability of treatment weighting to assess the impact of beta-interferon treatments in delaying disability progression in multiple sclerosis", Session on 'Causal Methods and Applications in Variable Selection, Genetics, Mediation and Survival Analysis', Section on Statistics in Epidemiology, 2013 Joint Statistical Meetings, August 3-8, 2013.

9.      Karim, M. E. *; Gustafson, P.; Petkau, J.; Shirani, A.; Zhao, Y.; Kingwell, E.; van der Kop, M.; Oger, J.; Tremlett, H. "A simulation study of methods used to reduce variability in the inverse probability of treatment weights for marginal structural Cox models", Annual Meeting of the Statistical Society of Canada, University of Alberta, Edmonton, Alberta, May 26-29, 2013.

10.   Karim, M. E. *; Gustafson, P.; Petkau, J.;  Shirani, A.;  Zhao, Y.;  Kingwell, E.; Evans, C.; van der Kop, M.;  Oger, J.; Tremlett, H. "Comparing the direct and approximate approaches to implement marginal structural Cox models: An Application to Multiple Sclerosis", Inaugural Statistical Society of Canada Student Conference, University of Alberta, Edmonton, Alberta, May 25, 2013.

11.   Karim, M. E. * “Reverse-engineering randomization!”, Joint UBC/SFU, Department of Statistics, University of British Columbia, March  2013.

12.   Karim, M. E. *; Gustafson, P.; Petkau, J.;  Zhao, Y.; Shirani, A.; Evans, C.; Kingwell, E.; van der Kop, M.; Tremlett, H. "A simulation study of the performance of the prescription time-distribution matching method to address immortal time bias", Session on 'Causal Inference in Epidemiology', Section on Statistics in Epidemiology, 2012 Joint Statistical Meetings, San Diego, July 28-August 2, 2012.

13.   Karim, M. E. *; Gustafson, P.; Petkau, J. "Generating survival data for fitting marginal structural Cox models using Stata", Stata Conference, San Diego, July 26–27, 2012.

14.   Karim, M. E. * “A Path to Causal Inference”, Joint UBC/SFU, Department of Statistics and Actuarial Science, Simon Fraser University, September 2011.

15.   Karim, M. E. *; Gustafson, P.; Petkau, J.; Shirani, A.; van der Kop, M.; Kingwell, E.; Zhao, Y.; Evans, C.; Tremlett, H. "Marginal Structural Models for Investigating Long-Term Effectiveness of a Time-Dependent Treatment: An Application to Multiple Sclerosis", Session on 'Innovative Approaches for Analyzing Repeated Measures Data', Section on Statistics in Epidemiology, 2011 Joint Statistical Meetings, Miami, Florida; July 31st, 2011.

 

·        Outreach

1.      Karim, M. E. * “Mediation analysis using administrative data”, BC-CDC, Vancouver, Oct 16, 2019

2.      Karim, M. E. * “Confounder selection principles: Statistical and epidemiologic considerations”,

§  Special seminar session on Epidemiologic Methodology, Institute of Statistical Research and Training, University of Dhaka, Bangladesh, Dec 26th, 2019

§  Epidemiology methods group meeting, VGH Eye Care Center, Vancouver, Oct 2nd, 2019

§  Stats group meeting, St. Paul's Hospital, Vancouver, Oct 7th, 2019

3.      Karim, M. E.* “Navigating complex survey data analysis for health research”, Statistics group seminar, St Paul’s Hospital, Vancouver, 10 March 2019.

4.      Karim, M. E. *  "Propensity score matching in presence of immortal time bias" November 2013, Brain Research Centre conference centre, Western Pacific endMS Research & Training Centre, UBC Hospital, Vancouver.

5.      Karim, M. E. * "How to estimate beta-interferon treatment effectiveness in MS using some fancy modelling", September 2011, Pharmacoepidemiology in MS Research Group (PiMS), Brain Research Centre conference centre, UBC Hospital, Vancouver.

 

·        Student Seminar Presentations

1.      Karim, M. E. * "Causal Inference Approaches for Dealing with Time-dependent Confounding in Longitudinal Studies, with Applications to Multiple Sclerosis Research", Biostatistical Research Group Seminar Series, Department of Statistics, University of British Columbia, December, 2014.

2.      Karim, M. E. * “Causal Inference from Observational Data using Propensity Scores”, Graduate Students Seminar Series, Department of Statistics, University of British Columbia, March, 2011.

3.      Karim, M. E. * “Estimating the causal effect of a treatment while time-dependent confounding is present: An illustration of the sequential Cox approach”, Graduate Students Seminar Series, Department of Statistics, University of British Columbia, September, 2011.

4.      Karim, M. E. * "Evaluating the Performance of Hypothesis Testing in Case-Control Studies with Exposure Misclassification, using Frequentist and Bayesian Techniques", Seminar Series, Department of Statistics, University of British Columbia, June, 2009.

5.      Karim, M. E. * “Comparisons of Different Frailty Models: A Simulation Study”, Thesis defense, Institute of Statistical Research and Training, University of Dhaka, Bangladesh, August, 2007.

6.      Karim, M. E. * "Modeling the Daily Rainfall Occurrence: A stochastic approach”, Project presentation, Institute of Statistical Research and Training, University of Dhaka, Bangladesh, 2005.

 

·        Abstracts / Posters [Presenting author is marked by *]

1.      Basham CA *, Karim ME, Cook VJ, Patrick DM, Johnston JC. Tuberculosis (TB) patients at increased risk of non-TB mortality: a population-based survival analysis of linked immigration and vital statistics data in British Columbia, Canada, 1985-2015. In: The International Union Against Tuberculosis and Lung Disease - North America Region; 24th Annual TB Conference; February 27-29, 2020; Chicago, IL.  Vancouver, BC: The Union-NAR / BC Lung Association; 2020. (scheduled)

2.      Jeong D*, Wong S, Karim ME, Butt ZA, Binka M, Adu P, Wilton J, Abdia Y, Yu A, Alvarez M, Bartlett S, Clementi E, Pearce M, Krajden M, Janjua N (2020) “For consideration for Canadian Liver Meeting and 9th Canadian Symposium on HCV”, Canadian Liver Meeting, February 27 - March 1, 2020 in Montreal, Canada (ID CLMHCV-1054) (scheduled)

3.      Manouchehrinia A*, McKay KA, Karim ME, Kagstrom S, Kavaliunas A, Berglund A, Lycke J, Peihl F, Hillert J, Kockum I, Olsson T. Effect of natalizumab on information processing speed in multiple sclerosis: a nationwide phase IV study. ECTRIMS 2019, Stockholm, Sweden. Multiple Sclerosis Journal. Vol. 25.URL: https://journals.sagepub.com/doi/pdf/10.1177/1352458519868080 (Last accessed: Jan 2, 2020)

4.      Atiquzzaman M*, Karim ME, Kopec J, Wong H, De Vera M, Anis A. Using External Data to Estimate Omitted Variables in Observational Data: A Plasmode Simulation Study Investigating the Relationship Between Osteoarthritis and Cardiovascular Diseases to Compare Alternative Approaches in Imputing the Body Mass Index Variable [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/using-external-data-to-estimate-omitted-variablesin-observational-data-a-plasmode-simulation-study-investigating-the-relationship-betweenosteoarthritis-and-cardiovascular-diseases-to-compare-altern/. Accessed November 4, 2019. URL: https://acrabstracts.org/abstract/using-external-data-to-estimate-omitted-variables-in-observational-data-a-plasmode-simulation-study-investigating-the-relationship-between-osteoarthritis-and-cardiovascular-diseases-to-compare-altern/ (Last accessed: Jan 2, 2020)

5.      Atiquzzaman M, Karim ME, Wong H, Kopec J, Vera MD , Anis A* (2019) Comparative cardiovascular safety of non-steroidal anti-inflammatory drugs (NSAIDs) among individuals with osteoarthritis; findings from provincial prescription claim records in British Columbia, Canada. Annual European Congress of Rheumatology EULAR 2019 Madrid, Spain, 12-15 June 2019 URL: https://ard.bmj.com/content/78/Suppl_2/1394.1 (Last accessed: Jan 2, 2020)

6.      Mosquera L*, Karim ME (2019) Comparing instrumental variable and naive methods for estimating the causal effect of treatment in pragmatic trials with non-compliance, The 2019 Atlantic Causal Inference Conference (ACIC), Montreal, May, 2019

7.      Sanders E*, Gustafson P, Karim ME (2019) Incorporating Partial Adherence into the Principal Stratification Analysis Framework, Annual Meeting of the Statistical Society of Canada, Calgary, May, 2019

8.      Karim ME*, Atiquzzaman M (2019) Mediating role of pain-medication in the increased risk of cardiovascular diseases among Canadian osteoarthritis patients, International Society for Clinical Biostatistics (ISCB) Annual Conference, July 2019 Leuven, Belgium

9.      Ouyang D*, Wong H, Gustafson P, Karim ME (2019) Estimating and using the attained power distribution to ensure we get the trial power we expect. 2019 Joint Statistical Meetings – Speed Presentation #304799, July 27 – August 1, 2019 Colorado

10.   Cordeiro J, et al. (2019) Using Home-Telemonitoring to Support COPD patient care: The nursing experience. BC Quality Forum, February 27-28th.

11.   Liu P*, Quinn R, Ronksley P, Bello A, Hemmelgarn B, Quan H, Tonelli M, Manns B, Weaver R, Tam-Tham H, Karim, M. E., Ravani P. (2018). Estimating the causal effect of referral for nephrology care on the survival of adults with advanced chronic kidney disease in a real-world clinical setting. 2018 International Population Data Linkage Conference [CA] URL: https://ijpds.org/article/view/611 (Last accessed: Jan 2, 2020)

12.   Kwon, J. Y., Park, M., Karim, M. E., & Sawatzky, R. (2018). Examining chronic conditions, health burden and gender, and the mediating role of distress. Quality of Life Research, 27, S112–S112.

13.   Atiquzzaman M*, Kopec J, Karim ME, Wong H, Anis A*. (2018). The role of nsaids in the association between osteoarthritis and cardiovascular diseases: a population-based cohort study. European League Against Rheumatism [CA] URL: https://ard.bmj.com/content/77/Suppl_2/144.2 (Last accessed: Jan 2, 2020)

14.   Atiquzzaman M, Kopec J, Karim ME, Wong H, Anis A. The role of NSAIDs in the association between osteoarthritis and cardiovascular diseases: a population-based cohort study. Ann Rheum Dis. 2018 Jun 1;77 (Suppl 2):144–144 [CA]

15.   Atiquzzaman M, Kopec J, Karim ME, Wong H, Anis A. Do Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) lead to increased risk for cardiovascular diseases (CVD) among people with osteoarthritis (OA)? Osteoporos Int. 2018 Apr;29 (S1):279–279. [CA]

16.   Atiquzzaman M*, Karim ME, Kopec J, Wong H, Anis A. (2018). Do non-steroidal anti-inflammatory drugs (NSAIDS) lead to increased risk for cardiovascular diseases (CVD) among people with osteoarthritis (OA)? WCO-IOF-ESCEO congress Krakow, Poland. [CA]

17.   Ho K*, Cordeiro J, Bhullar A, Abu-Laban R, Christenson J, Harps H, Hawkins N, Karim ME, Kim-Sing C, McGavin C, Mitton C, Smith T, Novak-Lauscher H, on behalf of the TEC4Home Innovation Community. (2018). TEC4Home Heart Failure: Using home telemonitoring to decrease ED readmissions and clinical flow.CAEP 2018 [CA]

18.   Puyat J*, Karim ME, Patten S, Evans C, Anis A. (2017). Using big data analytics to close the quality gap in depression care. 2017 Western Canadian Universities Big Data Health Conference, Poster [CA].

19.   Ho K*, Novak LH, Cordeiro J, Mitton C, Wong H, Karim ME, Bhullar A, TEC4Home Health Innovation Community.(2017). TEC4Home: Tele-monitoring to support the transition of Heart Failure patient care from hospital to home. Putting Patients First: Partnerships for Better Health Research, BC SUPPORT Unit provincial conference, Vancouver, BC, Nov 9th. [CA]

20.   Liu P*, Quinn R, Ronksley P, Bello A, Hemmelgarn B, Quan H, Tonelli M, Manns B, Weaver R, Tam-Tham H, Karim ME, Ravani P (2017) People with chronic kidney disease: Who to refer, when to refer, and the impact on outcomes. Kidney Health Strategic Clinical Network, July 20, 2017, Edmonton, Alberta. [CA] URL: https://www.albertahealthservices.ca/assets/about/scn/ahs-scn-kh-nephrology-referrals-who-when-impact-liu.pdf (last accessed: 02 Jan, 2020)

21.   Shirani A*, Zhao Y, Karim ME, Petkau J, Gustafson P, Evans C, Kingwell E, van der Kop M, Oger J, UBC MS Clinic Neurologists, Tremlett H (2013) Investigation of heterogeneity in the association between interferon beta and disability progression in multiple sclerosis: an observational study from British Columbia, Canada. Tools for detecting therapeutic response, ECTRIMS/RIMS meeting, Copenhagen, Denmark 2 5 October 2013. [MC]

22.   Shirani A*, Zhao Y, Karim ME, Evans C, Kingwell E, van der Kop M, Oger J, Petkau J, Gustafson P, Tremlett H (2012). Association Between Use of Interferon Beta and Progression of Disability in Patients with Relapsing-Remitting Multiple Sclerosis. 2012 Symposium of the European Charcot Foundation. 29 Nov - 1 Dec, Marbella, Spain. [MC]

23.   Evans C*, Zhao Y, Shirani A, Kingwell E, van der Kop M, Karim ME, Gustafson P, Petkau J, Tremlett H (2010) The BeAMS Study: Long-term benefits and adverse effects of beta-interferons for multiple sclerosis: Impact on hospital services utilization. Proceedings of endMS Conference 2010; p. 38. endMS Conference 2010, Whistler, BC, Canada, 6-9 December 2010. [CA]